ROS 234 dioxalate

Catalog # Availability Size / Price Qty
2034/10
2034/50
Cat.No. 2034 - ROS 234 dioxalate | C13H15N5.2C2H2O4 | CAS No. 184576-87-2
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Description: Potent H3 antagonist

Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate

Purity: ≥99%

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Biological Activity

Potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data

M.Wt:
421.37
Formula:
C13H15N5.2C2H2O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
184576-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. CNS access of selected H3-antagonists: ex vivo binding study in rats.
    Ballabeni et al.
    Inflamm.Res., 2002;51:S55
  2. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.
    Mor et al.
    Bioorg.Med.Chem.Lett., 2004;12:663

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