ROS 234 dioxalate

Key Product Details

Product Description

ROS 234 dioxalate is a potent H₃ antagonist (pK_B at guinea-pig ileum H₃-receptor = 9.46). Limited blood brain barrier permeability (ED₅₀ = 19.12 mg/kg i.p.).

Product Specifications for ROS 234 dioxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ROS 234 dioxalate

The following data is based on the product molecular weight 421.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.75 mL	23.73 mL	47.46 mL
2.5 mM	0.95 mL	4.75 mL	9.49 mL
5 mM	0.47 mL	2.37 mL	4.75 mL
25 mM	0.09 mL	0.47 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mor Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H₃-antagonists. Bioorg.Med.Chem.Lett.
• Ballabeni CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 2002 PMID: 12013409

Product Documents for ROS 234 dioxalate