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ROS 234 dioxalate

2034 Datasheet / COA / SDS

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2034 has been discontinued.
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ROS 234 dioxalate | CAS No. 1781941-93-2 | Histamine H3 Receptor Antagonists
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Description: Potent H3 antagonist

Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate

Purity: ≥99%

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Biological Activity

ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data

M.Wt:
421.37
Formula:
C13H15N5.2C2H2O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1781941-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. CNS access of selected H3-antagonists: ex vivo binding study in rats.
    Ballabeni et al.
    Inflamm.Res., 2002;51:S55
  2. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.
    Mor et al.
    Bioorg.Med.Chem.Lett., 2004;12:663

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