ROS 234 dioxalate

Discontinued Product

2034 has been discontinued.
View all Histamine H3 Receptor Antagonists products.
ROS 234 dioxalate | CAS No. 1781941-93-2 | Histamine H3 Receptor Antagonists
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Description: Potent H3 antagonist

Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate

Purity: ≥99%

Product Details

Biological Activity

ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data

Soluble to 50 mM in water and to 50 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. CNS access of selected H3-antagonists: ex vivo binding study in rats.
    Ballabeni et al.
    Inflamm.Res., 2002;51:S55
  2. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.
    Mor et al.
    Bioorg.Med.Chem.Lett., 2004;12:663

Product Datasheets

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