Chemical Name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
Biological ActivityRosuvastatin calcium is a potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Enhances lentiviral transduction of natural killer cells. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
McTaggart et al.
Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor.
Gong et al.
Mol.Ther.Methods Clin.Dev., 2020;17:634
Citation for Rosuvastatin calcium
The citations listed below are publications that use Tocris products. Selected citations for Rosuvastatin calcium include:
1 Citation: Showing 1 - 1
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
Authors: Rojo-Arreola Et al.
PLoS One 2014;9:e87594
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