Catalog Number: 3315
Chemical Name: 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride
Biological Activity
Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.
Technical Data
  • M.Wt:
    411.8
  • Formula:
    C19H13N5O4.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    152815-28-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.
    Alvarez et al.
    Mol.Pharmacol., 1995;48:616
  2. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils.
    Kaneko et al.
    Cell.Signal., 1995;7:527
  3. AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.
    Bajpai et al.
    Biol.Reprod., 2006;74:109
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 25344 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
    Authors: Boomkamp Et al.
    Cell Rep 2014;171:2385

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