RS 25344 hydrochloride
Chemical Name: 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride
Biological ActivityPotent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.
Alvarez et al.
Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils.
Kaneko et al.
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.
Bajpai et al.
Citation for RS 25344 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 25344 hydrochloride include:
1 Citation: Showing 1 - 1
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
Authors: Boomkamp Et al.
Cell Rep 2014;171:2385
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