Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50
values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro
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Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.
Alvarez et al.
Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils.
Kaneko et al.
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.
Bajpai et al.
The citations listed below are publications that use Tocris products. Selected citations for RS 25344 hydrochloride include:
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