Catalog Number: 0987
Chemical Name: (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
Biological Activity
α2-adrenoreceptor antagonist (Kd values are; 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat).
Technical Data
  • M.Wt:
    400.96
  • Formula:
    C19H28N2O3S.HCl
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    186002-54-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Roche Bioscience
Background References
  1. Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors.
    Hume et al.
    Eur.J.Pharmacol., 1996;317:67
  2. (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α2-adrenoceptor antagonist.
    Clark et al.
    J. Med. Chem., 1989;32:2034
  3. [3H]RS79948-197 binding to rat, guinea pig and pig α2A-, α2B and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine.
    Uhlen et al.
    Eur.J.Pharmacol., 1998;343:93
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 79948 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology 2017;118:79
  2. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
    Authors: Zacharia Et al.
    PLoS One 2013;8:e65969

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