Rigidified analog of MPPG
(Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50
= 30 μ
M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion.
Krenz et al.
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.
Xi et al.
Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists.
Ma et al.