(RS)-APICA

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1073/10
1073/50
(RS)-APICA | CAS No. 170847-18-4 | Group II mGluR Antagonists
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Description: Selective group II mGlu antagonist

Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid

Product Details
Citations (2)
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Biological Activity

(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data

M.Wt:
257.18
Formula:
C10H12NO5P
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Storage:
Desiccate at +4°C
CAS No:
170847-18-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion.
    Krenz et al.
    J.Neurophysiol., 2000;83:1188
  2. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.
    Xi et al.
    J.Pharmacol.Exp.Ther., 2002;300:162
  3. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists.
    Ma et al.
    Bioorg.Med.Chem.Lett., 1997;7:1195

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Citations for (RS)-APICA

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