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(RS)-APICA

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(RS)-APICA | CAS No. 170847-18-4 | Group II mGluR Antagonists
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Description: Selective group II mGlu antagonist

Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid

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Citations (2)
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Biological Activity

(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data

M.Wt:
257.18
Formula:
C10H12NO5P
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Storage:
Desiccate at +4°C
CAS No:
170847-18-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion.
    Krenz et al.
    J.Neurophysiol., 2000;83:1188
  2. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.
    Xi et al.
    J.Pharmacol.Exp.Ther., 2002;300:162
  3. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists.
    Ma et al.
    Bioorg.Med.Chem.Lett., 1997;7:1195

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Citations for (RS)-APICA

The citations listed below are publications that use Tocris products. Selected citations for (RS)-APICA include:

2 Citations: Showing 1 - 2

  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  2. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
    Authors: Jiang Et al.
    J Neurosci  2006;26:4318

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VersaClone cDNA Plasmids

Human mGluR2 (NP_000830) VersaClone cDNA

RDC0989

Human mGluR3 (NP_000831) VersaClone cDNA

RDC1012

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