Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.
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Diverse mechanisms of antiepileptic drugs in the development pipeline.
Rogawski et al.
Epilepsy Res., 2006;69:273
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
White et al.