Ruxolitinib

Catalog # Availability Size / Price Qty
7064/50
Ruxolitinib | CAS No. 941678-49-5 | JAK Kinase Inhibitors
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Description: Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
Alternative Names: INCB018424

Chemical Name: (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective JAK1/2 inhibitor (IC50 values are 3.3 and 2.8 nM, respectively). Exhibits selectivity for JAK1/2 over Tyk2 and JAK3 (~6-fold and >130-fold, respectively). Exhibits no significant inhibition against a commercial panel of 26 additional kinases. Inhibits JAK2V617F-mediated signaling and proliferation in Ba/F3 cells and HEL cells. Increases survival rates in a JAK2V617F-driven mouse model. Identified as targeting human host proteins that interact with SARS-CoV-2.Orally bioavailable.

Phosphate salt (Cat. No. 7048) also available.

Technical Data

M.Wt:
306.37
Formula:
C17H18N6
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
941678-49-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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