RVG29-Cys

Name: RVG29-Cys
Brand: Tocris Bioscience
SKU: 8903
Price: 255 USD
Availability: InStock

Tocris Bioscience | Catalog # 8903

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Nicotinic acetylcholine receptor targeting peptide for neuronal delivery

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Nicotinic acetylcholine receptor targeting peptide for neuronal delivery

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Product Description

RVG29-Cys is a peptide derived from rabies virus glycoprotein (RVG) able to specifically bind on the nicotinic acetylcholine receptors (nAchR) present on neuronal cells. RVG29-Cys can be used to functionalize LNPs via thiol-maleimide click chemistry for targeting nAchR present on blood-brain barrier (BBB). mRNA LNPs functionalized with RVG29-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.

Product Specifications for RVG29-Cys

Molecular Weight

3369.79

Formula

C₁₄₄H₂₂₂N₄₄O₄₄S₃

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1404289-25-3

PubChem ID

172898615

InChI Key

SQWGWNJDPJYWQQ-FMHCIDBQSA-N

SMILES

O=C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCSC)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(NCC(N[C@@H]([C@H](O)C)C(N6[C@@H](CCC6)C(N[C@@H](CS)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC8=CC=C(C=C8)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

Concentration

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g/mol

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Background References

References are publications that support the biological activity of the product.

Liu Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials 2009 PMID: 19467700
Han Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett. 2025 PMID: 39688915

Product Documents for RVG29-Cys

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for RVG29-Cys

For research use only

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