Home / Integrin Receptor Inhibitors / RWJ 50271

RWJ 50271

4227 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4227/10
4227/50
RWJ 50271 | CAS No. 162112-37-0 | Integrin Receptor Inhibitors
1 Image
Description: Inhibitor of LFA-1/ICAM mediated cell adhesion

Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Technical Data

M.Wt:
410.41
Formula:
C18H17F3N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
162112-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
    Sanfilippo et al.
    J.Med.Chem., 1995;38:1057

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for RWJ 50271

The citations listed below are publications that use Tocris products. Selected citations for RWJ 50271 include:

1 Citation: Showing 1 - 1

  1. Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture.
    Authors: Takizawa
    Exp Cell Res  2017;358(2):441

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Human ICAM-1/CD54 (NP_000192) VersaClone cDNA

RDC1030
1 Citations

Human Integrin beta 2/CD18 (NP_000202) VersaClone cDNA

RDC0398

Mouse ICAM-1/CD54 (NP_034623) VersaClone cDNA

RDC1449

Mouse Integrin beta 2/CD18 (NP_032430) VersaClone cDNA

RDC1476

Reviews for RWJ 50271

There are currently no reviews for this product. Be the first to review RWJ 50271 and earn rewards!

Have you used RWJ 50271?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.