RWJ 50271

Catalog # Availability Size / Price Qty
4227/10
4227/50
Cat.No. 4227 - RWJ 50271 | C18H17F3N4O2S | CAS No. 162112-37-0
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Description: Inhibitor of LFA-1/ICAM mediated cell adhesion

Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Technical Data

M.Wt:
410.41
Formula:
C18H17F3N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
162112-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Background References

  1. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
    Sanfilippo et al.
    J.Med.Chem., 1995;38:1057

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Citation for RWJ 50271

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