RWJ 50271
Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
Purity: ≥99%
Biological Activity
Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
Sanfilippo et al.
J.Med.Chem., 1995;38:1057
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Citation for RWJ 50271
The citations listed below are publications that use Tocris products. Selected citations for RWJ 50271 include:
1 Citation: Showing 1 - 1
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Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture.
Authors: Takizawa
Exp Cell Res 2017;358(2):441
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