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RWJ 50271

4227 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4227/10
4227/50
Cat.No. 4227 - RWJ 50271 | C18H17F3N4O2S | CAS No. 162112-37-0
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Description: Inhibitor of LFA-1/ICAM mediated cell adhesion

Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Technical Data

M.Wt:
410.41
Formula:
C18H17F3N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
162112-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Background References

  1. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
    Sanfilippo et al.
    J.Med.Chem., 1995;38:1057

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Citation for RWJ 50271

The citations listed below are publications that use Tocris products. Selected citations for RWJ 50271 include:

1 Citation: Showing 1 - 1

  1. Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture.
    Authors: Takizawa
    Exp Cell Res  2017;358(2):441

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VersaClone cDNA Plasmids

Mouse ICAM-1/CD54 (NP_034623) VersaClone cDNA

RDC1449

Human ICAM-1/CD54 (NP_000192) VersaClone cDNA

RDC1030

Human Integrin beta 2/CD18 (NP_000202) VersaClone cDNA

RDC0398

Mouse Integrin beta 2/CD18 (NP_032430) VersaClone cDNA

RDC1476

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