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RWJ 50271

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RWJ 50271 | CAS No. 162112-37-0 | Integrin Receptor Inhibitors
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Description: Inhibitor of LFA-1/ICAM mediated cell adhesion

Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide

Purity: ≥99%

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Biological Activity

RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Technical Data

M.Wt:
410.41
Formula:
C18H17F3N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
162112-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
    Sanfilippo et al.
    J.Med.Chem., 1995;38:1057

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