Catalog Number: 4227
Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
Biological Activity
Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).
Technical Data
  • M.Wt:
    410.41
  • Formula:
    C18H17F3N4O2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    162112-37-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
    Sanfilippo et al.
    J.Med.Chem., 1995;38:1057
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RWJ 50271 include:

1 Citations: Showing 1 - 1

  1. Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture.
    Authors: Takizawa
    Exp Cell Res 2017;358(2):441

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