Catalog Number: 1771
Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride
Biological Activity
Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors.
    Lima et al.
    J.Neural Transm., 1997;104:1059
  2. S 14506: novel receptor coupling at 5-HT1A receptors.
    Milligan et al.
    Neuropharmacology, 2001;40:334
  3. S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent.
    Colpaert et al.
    Drug Dev.Res., 1992;26:21
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