S 14506 hydrochloride
Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride
Biological ActivityHighly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors.
Lima et al.
J.Neural Transm., 1997;104:1059
S 14506: novel receptor coupling at 5-HT1A receptors.
Milligan et al.
S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent.
Colpaert et al.
Drug Dev.Res., 1992;26:21
Citation for S 14506 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for S 14506 hydrochloride include:
1 Citation: Showing 1 - 1
Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
Authors: Walory Et al.
Int J Mol Sci 2018;19
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