Highly potent selective 5-HT1A
receptor full agonist (pKi
values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A
receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo
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Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors.
Lima et al.
J.Neural Transm., 1997;104:1059
S 14506: novel receptor coupling at 5-HT1A receptors.
Milligan et al.
S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent.
Colpaert et al.
Drug Dev.Res., 1992;26:21