S 38093

Key Product Details

Product Description

S 38093 is a H₃ antagonist and inverse agonist (K_i values are 8.8, 1.2 and 1.44 μM, at rat, human and mouse, respectively). Exhibits no activity at other histaminergic receptors. Antagonizes agonist action at mouse H₃ receptors (K_B = 0.65 μM). Displays inverse agonist action in cells expressing a high H₃ receptor density, (EC₅₀ values are 9 and 1.7 μM, at human and rat H₃ receptors, respectively). Exhibits antihyperalgesic effect in a mouse diabetic neuropathy model in vivo. Promotes hippocampal neurogenesis in a mouse Alzheimer's disease model. Antinociceptive and procognitive. Also σ₁ receptor antagonist. Exhibits ~30-fold selecitivity for σ₁ over H₃ and occupies σ₁ but not H₃ receptors at procognitive does in mice.

Product Specifications for S 38093

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for S 38093

The following data is based on the product molecular weight 288.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.34 mL	34.68 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chaumette Effects of S 38093, an antagonist/inverse agonist of histamine H₃ receptors, in models of neuropathic pain in rats. Eur.J.Pain. 2018 PMID: 28877402
• Riddy Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists. Neuropharmacology 2019 PMID: 30359639
• Guilloux S 38093, a histamine H₃ antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci.Rep. 2017 PMID: 28218311

Product Documents for S 38093