Chemical Name: (S)-α-Methyl-4-carboxyphenylglycine
Biological Activity(S)-MCPG is an active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.
Racemate also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Phenylglycine derivatives as metabotropic glutamate receptor antagonists.
Collingridge and Watkins
Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning.
Bordi et al.
Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones.
Jane et al.
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
Sekiyama et al.
Citations for (S)-MCPG
The citations listed below are publications that use Tocris products. Selected citations for (S)-MCPG include:
24 Citations: Showing 1 - 10
Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Authors: Szokol Et al.
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
Authors: Gu Et al.
Nat Commun 2015;6:6789
Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
Authors: Rosa Et al.
J Neurosci 2015;4
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Authors: Stephen Et al.
Proc Natl Acad Sci U S A 2015;35:15996
Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
Authors: Nieus Et al.
Front Cell Neurosci 2014;8:246
Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
Authors: Platt Et al.
PLoS One 2012;7:e36397
Optimization of a GCaMP calcium indicator for neural activity imaging.
Authors: Akerboom Et al.
J Neurosci 2012;32:13819
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
Authors: Navarrete Et al.
PLoS Biol 2012;10:e1001259
CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
J Neurophysiol 2011;105:1051
Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons.
Authors: Shinoda Et al.
PLoS One 2010;5:e10390
A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.
Authors: Reissner Et al.
J Neurosci 2010;30:8797
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
Authors: Bagayogo and Dreyfus
ASN Neuro 2009;1
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Authors: Fukunaga Et al.
Br J Pharmacol 2007;151:870
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Authors: Bender Et al.
J Neurosci 2006;26:4166
Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores.
Authors: Kumar and Foster
J Neurophysiol 2004;91:2437
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
Authors: Melyan Et al.
J Neurosci 2004;24:4530
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
Authors: Melis Et al.
J Neurosci 2004;24:10707
DA controls the firing pattern of DA neurons via a network feedback mechanism.
Authors: Paladini Et al.
Nat Neurosci 2003;100:2866
Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
Authors: Matthies Et al.
Learn Mem 2000;7:227
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
Authors: Min Et al.
Proc Natl Acad Sci U S A 1999;96:9932
Developmental regulation of spine motility in the mammalian central nervous system.
Authors: Dunaevsky Et al.
Proc Natl Acad Sci U S A 1999;96:13438
Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
Authors: Vogt and Nicoll
Proc Natl Acad Sci U S A 1999;96:1118
Regulation of N-MthD.-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
Authors: Colwell Et al.
Front Cell Neurosci 1996;93:1200
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When mGluRs were suppressed with 1 mM (S)-MCPG, NMDAR effect was not enough powerful to generate action potentials in response to repetitive electrical stimulation of neural tissue. Figure: evoked post-synaptic potentials with action potentials (under control) and without action potentials (after application of MCPG.