(S)-MCPG

Catalog # Availability Size / Price Qty
0337/10
0337/50
(S)-MCPG | CAS No. 150145-89-4 | Group I mGluR Antagonists
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Description: Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)

Chemical Name: (S)-α-Methyl-4-carboxyphenylglycine

Purity: ≥99%

Product Details
Citations (24)
Supplemental Products
Reviews (1)

Biological Activity

(S)-MCPG is an active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.

Racemate also available.

Technical Data

M.Wt:
209.2
Formula:
C10H11NO4
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
≥99%
Storage:
Store at RT
CAS No:
150145-89-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (S)-MCPG

The citations listed below are publications that use Tocris products. Selected citations for (S)-MCPG include:

24 Citations: Showing 1 - 10

  1. Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
    Authors: Szokol Et al.
    Elife  2015;9:49
  2. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
    Authors: Gu Et al.
    Nat Commun  2015;6:6789
  3. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Neurosci  2015;4
  4. Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
    Authors: Stephen Et al.
    Proc Natl Acad Sci U S A  2015;35:15996
  5. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
    Authors: Nieus Et al.
    Front Cell Neurosci  2014;8:246
  6. Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One  2012;7:e36397
  7. Optimization of a GCaMP calcium indicator for neural activity imaging.
    Authors: Akerboom Et al.
    J Neurosci  2012;32:13819
  8. Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
    Authors: Navarrete Et al.
    PLoS Biol  2012;10:e1001259
  9. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol  2011;105:1051
  10. Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons.
    Authors: Shinoda Et al.
    PLoS One  2010;5:e10390
  11. A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.
    Authors: Reissner Et al.
    J Neurosci  2010;30:8797
  12. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  13. Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
    Authors: Bagayogo and Dreyfus
    ASN Neuro  2009;1
  14. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
    Authors: Fukunaga Et al.
    Br J Pharmacol  2007;151:870
  15. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci  2006;26:4166
  16. Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores.
    Authors: Kumar and Foster
    J Neurophysiol  2004;91:2437
  17. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci  2004;24:4530
  18. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
    Authors: Melis Et al.
    J Neurosci  2004;24:10707
  19. DA controls the firing pattern of DA neurons via a network feedback mechanism.
    Authors: Paladini Et al.
    Nat Neurosci  2003;100:2866
  20. Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
    Authors: Matthies Et al.
    Learn Mem  2000;7:227
  21. Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
    Authors: Min Et al.
    Proc Natl Acad Sci U S A  1999;96:9932
  22. Developmental regulation of spine motility in the mammalian central nervous system.
    Authors: Dunaevsky Et al.
    Proc Natl Acad Sci U S A  1999;96:13438
  23. Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
    Authors: Vogt and Nicoll
    Proc Natl Acad Sci U S A  1999;96:1118
  24. Regulation of N-MthD.-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
    Authors: Colwell Et al.
    Front Cell Neurosci  1996;93:1200

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(S)-MCPG as a blocker of mGluR action
By Sergiy Sylantyev on 05/26/2019
Application: Species: Rat

When mGluRs were suppressed with 1 mM (S)-MCPG, NMDAR effect was not enough powerful to generate action potentials in response to repetitive electrical stimulation of neural tissue. Figure: evoked post-synaptic potentials with action potentials (under control) and without action potentials (after application of MCPG.

PMID: 23395378

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