Catalog Number: 0337
Chemical Name: (S)-α-Methyl-4-carboxyphenylglycine
Biological Activity
Active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.

Available as part of the Group I mGlu Receptor Tocriset™, Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™. Racemate also available.

Technical Data
  • M.Wt:
    209.2
  • Formula:
    C10H11NO4
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    150145-89-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning.
    Bordi et al.
    Neuropharmacology, 1996;35:1557
  2. Phenylglycine derivatives as metabotropic glutamate receptor antagonists.
    Collingridge and Watkins
    TiPS, 1994;15:333
  3. Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones.
    Jane et al.
    Neuropharmacology, 1993;32:725
  4. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
    Sekiyama et al.
    Br. J. Pharmacol., 1996;117:1493
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-MCPG include:

18 Citations: Showing 1 - 10
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  1. Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
    Authors: Szokol Et al.
    Elife 2015;9:49
  2. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
    Authors: Gu Et al.
    Nat Commun 2015;6:6789
  3. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Neurosci 2015;4
  4. Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
    Authors: Stephen Et al.
    Proc Natl Acad Sci U S A 2015;35:15996
  5. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
    Authors: Nieus Et al.
    Front Cell Neurosci 2014;8:246
  6. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One 2012;7:e36397
  7. Optimization of a GCaMP calcium indicator for neural activity imaging.
    Authors: Akerboom Et al.
    J Neurosci 2012;32:13819
  8. Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
    Authors: Navarrete Et al.
    PLoS Biol 2012;10:e1001259
  9. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol 2011;105:1051
  10. Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons.
    Authors: Shinoda Et al.
    PLoS One 2010;5:e10390
  11. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
    Authors: Fukunaga Et al.
    Br J Pharmacol 2007;151:870
  12. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci 2006;26:4166
  13. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci 2004;24:4530
  14. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism.
    Authors: Paladini Et al.
    Nat Neurosci 2003;100:2866
  15. Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
    Authors: Matthies Et al.
    Learn Mem 2000;7:227
  16. Developmental regulation of spine motility in the mammalian central nervous system.
    Authors: Dunaevsky Et al.
    Proc Natl Acad Sci U S A 1999;96:13438
  17. Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
    Authors: Vogt and Nicoll
    Proc Natl Acad Sci U S A 1999;96:1118
  18. Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
    Authors: Colwell Et al.
    Front Cell Neurosci 1996;93:1200
Expand to show all 18 Citations

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