Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine
Biological Activity(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Phenylglycine derivatives as metabotropic glutamate receptor antagonists.
Collingridge and Watkins
Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1.
Joly et al.
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
Eaton et al.
Citations for (RS)-MCPG
The citations listed below are publications that use Tocris products. Selected citations for (RS)-MCPG include:
12 Citations: Showing 1 - 10
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Authors: Tang Et al.
J Neurosci 2015;35:3016
Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
Authors: Oh Et al.
Proc Natl Acad Sci U S A 2013;110:E305
Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
Authors: Zhang and Lisman
Cereb Cortex 2012;107:1058
Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Authors: Tronson Et al.
J Neurosci 2010;68:1007
Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
Authors: Petzold Et al.
Biol Psychiatry 2008;58:897
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Authors: Shankar Et al.
Nat Med 2008;14:837
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
Authors: Muddashetty Et al.
J Neurosci 2007;27:5338
Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
Authors: Jan and Westbrook
J Neurosci 2007;27:132
Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
Authors: Takayasu Et al.
J Neurophysiol 2006;26:6563
BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition.
Authors: Ohba Et al.
Proc Natl Acad Sci U S A 2005;15:291
On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus.
Authors: Zhuo Et al.
Learn Mem 1999;5:467
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(RS)-MCPG was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate and glycine, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG works as expected, but takes quite a long time to dissolve for stock preparation.