(RS)-MCPG

Catalog # Availability Size / Price Qty
0336/10
0336/50
(RS)-MCPG | CAS No. 146669-29-6 | Group I mGluR Antagonists
1 Image
Description: Non-selective mGlu antagonist

Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine

Purity: ≥99%

Product Details
Citations (12)
Supplemental Products
Reviews (1)

Biological Activity

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer and Sodium Salt also available.

Technical Data

M.Wt:
209.2
Formula:
C10H11NO4
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
≥99%
Storage:
Store at RT
CAS No:
146669-29-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for (RS)-MCPG

The citations listed below are publications that use Tocris products. Selected citations for (RS)-MCPG include:

12 Citations: Showing 1 - 10

  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  2. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  3. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
    Authors: Oh Et al.
    Proc Natl Acad Sci U S A  2013;110:E305
  4. Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
    Authors: Zhang and Lisman
    Cereb Cortex  2012;107:1058
  5. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
    Authors: Tronson Et al.
    J Neurosci  2010;68:1007
  6. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
    Authors: Petzold Et al.
    Biol Psychiatry  2008;58:897
  7. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
    Authors: Shankar Et al.
    Nat Med  2008;14:837
  8. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
    Authors: Muddashetty Et al.
    J Neurosci  2007;27:5338
  9. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
    Authors: Jan and Westbrook
    J Neurosci  2007;27:132
  10. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
    Authors: Takayasu Et al.
    J Neurophysiol  2006;26:6563

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for (RS)-MCPG

Average Rating: 4 (Based on 1 Review)

5 Star
0%
4 Star
100%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used (RS)-MCPG?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Suppression of mGluRs activated by glutamate application
By Sergiy Sylantyev on 10/15/2020
Application: Species: Human

(RS)-MCPG was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate and glycine, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG works as expected, but takes quite a long time to dissolve for stock preparation.

Reference

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.