(RS)-MCPG

  ( 12 citations )    
Product Datasheet
Catalog Number:0336
Chemical Name:(RS)-α-Methyl-4-carboxyphenylglycine
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer and Sodium Salt also available.

Technical Data
  • M.Wt:
    209.2
  • Formula:
    C10H11NO4
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    146669-29-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-MCPG include:

12 Citations: Showing 1 - 10
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  2. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  3. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
    Authors: Oh Et al.
    Proc Natl Acad Sci U S A  2013;110:E305
  4. Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
    Authors: Zhang and Lisman
    Cereb Cortex  2012;107:1058
  5. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
    Authors: Tronson Et al.
    J Neurosci  2010;68:1007
  6. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
    Authors: Petzold Et al.
    Biol Psychiatry  2008;58:897
  7. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
    Authors: Shankar Et al.
    Nat Med  2008;14:837
  8. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
    Authors: Muddashetty Et al.
    J Neurosci  2007;27:5338
  9. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
    Authors: Jan and Westbrook
    J Neurosci  2007;27:132
  10. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
    Authors: Takayasu Et al.
    J Neurophysiol  2006;26:6563
  11. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition.
    Authors: Ohba Et al.
    Proc Natl Acad Sci U S A  2005;15:291
  12. On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus.
    Authors: Zhuo Et al.
    Learn Mem  1999;5:467
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