(RS)-MCPG

Tocris Bioscience | Catalog # 0336

Non-selective mGlu antagonist
Tocris Bioscience

Key Product Details

Description

Non-selective mGlu antagonist
View all Group I mGluR Antagonists »

Product Description

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer and Sodium Salt also available.

Product Specifications for (RS)-MCPG

Molecular Weight

209.20

Formula

C10H11NO4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(RS)-α-Methyl-4-carboxyphenylglycine

CAS Number

146669-29-6

PubChem ID

1222

InChI Key

DNCAZYRLRMTVSF-UHFFFAOYSA-N

SMILES

NC(C(O)=O)(C)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 100

Preparing Stock Solutions for (RS)-MCPG

The following data is based on the product molecular weight 209.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.78 mL 23.90 mL 47.80 mL
5 mM 0.96 mL 4.78 mL 9.56 mL
10 mM 0.48 mL 2.39 mL 4.78 mL
50 mM 0.10 mL 0.48 mL 0.96 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for (RS)-MCPG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (RS)-MCPG

For research use only

Customer Reviews for (RS)-MCPG (1)

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  • Suppression of mGluRs activated by glutamate application
    Name: Sergiy Sylantyev
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    Verified Customer | Posted 10/15/2020
    (RS)-MCPG was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate and glycine, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG works as expected, but takes quite a long time to dissolve for stock preparation.
    (RS)-MCPG 0336

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