Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50
= 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50
= 140 nM). Induces mitotic arrest in HeLa cells with an IC50
of 700 nM. Displays antitumor activity.
Soluble to 50 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities.
DeBonis et al.
Mol.Cancer Ther., 2004;3:1079
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5.
Brier et al.
The citations listed below are publications that use Tocris products. Selected citations for S-Trityl-L-cysteine include:
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