S-Trityl-L-cysteine

Tocris Bioscience | Catalog # 2191

Potent, selective inhibitor of mitotic kinesin Eg5
Tocris Bioscience
Discontinued Product
2191 has been discontinued. View all Kinesin Inhibitors products.

Key Product Details

Description

Potent, selective inhibitor of mitotic kinesin Eg5

Alternative Names

NSC 83265
View all Kinesin Inhibitors »

Product Description

S-Trityl-L-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

Product Specifications for S-Trityl-L-cysteine

Molecular Weight

363.47

Formula

C22H21NO2S

Storage

Store at +4°C

Chemical Name

S-(Triphenylmethyl)-L-cysteine

CAS Number

2799-07-7

PubChem ID

7271795

InChI Key

DLMYFMLKORXJPO-HXUWFJFHSA-N

SMILES

N[C@@H](C(O)=O)CSC(C2=CC=CC=C2)(C3=CC=CC=C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.17 50

Preparing Stock Solutions for S-Trityl-L-cysteine

The following data is based on the product molecular weight 363.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.50 mL 27.51 mL 55.03 mL
2.5 mM 1.10 mL 5.50 mL 11.01 mL
5 mM 0.55 mL 2.75 mL 5.50 mL
25 mM 0.11 mL 0.55 mL 1.10 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 46 publications citing the usage of this product.

Product Documents for S-Trityl-L-cysteine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for S-Trityl-L-cysteine

For research use only

Related Research Areas

Microtubules

Citations for S-Trityl-L-cysteine

Customer Reviews for S-Trityl-L-cysteine (1)

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  • STLC block cells at mitotic entry
    Name: Valeria Marotta
    Species: Human
    Cell Line/Tissue: U2OS
    Verified Customer | Posted 10/07/2020
    I used the product to synchronise the cells at mitotic entry.
    S-Trityl-L-cysteine 2191

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