S3QEL 2

Catalog # Availability Size / Price Qty
5735/10
5735/50
Cat.No. 5735 - S3QEL 2 | C19H25N5 | CAS No. 890888-12-7
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Description: Suppressor of complex III superoxide production

Chemical Name: 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥98%

Product Details
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Biological Activity

Suppresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation (IC50 = 1.7 μM). Suppresses HIF-1α accumulation and enhances survival and function of primary pancreatic islets in vitro. Cell permeable.

Technical Data

M.Wt:
323.44
Formula:
C19H25N5
Solubility:
Soluble to 20 mM in DMSO with gentle warming and to 20 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
890888-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Suppressors of superoxide production from mitochondrial complex III.
    Orr et al.
    Nat.Chem.Biol., 2015;11:834

Product Datasheets

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