Catalog Number: 4951
Chemical Name: 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride
Biological Activity
Selective σ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.
    Brain, 2011;134:732
  2. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist.
    Matsuno et al.
    Eur.J.Pharmacol., 1996;306:271
  3. Stimulation of s1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy.
    Tagashira et al.
    Biochim.Biophys.Acta, 2013;1830:3082
  4. σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503.
    Lever et al.
    Synapse, 2006;59:350
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