1 receptor agonist (IC50
= 17.4 nM). Exhibits selectivity for σ
1 over σ
2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro
and attenuates myocardial hypertrophy in vivo
. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.
Binding properties of SA4503, a novel and selective sigma 1 receptor agonist.
Matsuno et al.
Stimulation of s1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy.
Tagashira et al.
σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503.
Lever et al.