SA 4503 dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:4951
Chemical Name:1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride
Product Details
Citations (1)
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Biological Activity
Selective σ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.
Technical Data
  • M.Wt:
    441.43
  • Formula:
    C23H32N2O2.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    165377-44-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SA 4503 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552

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