SA 57
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Description: Potent FAAH inhibitor
Chemical Name: 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester
Purity: ≥99%
Biological Activity
Potent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 <10 nM). Also inhibits MAGL at higher concentrations (IC50 values are 410 nM and 1.4 μM respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 in vivo.Technical Data
M.Wt:
338.83
Formula:
C17H23ClN2O3
Solubility:
Soluble to 25 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1346169-63-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.
Niphakis et al.
ACS Chem.Neurosci., 2012;3:418 -
Discriminative stimulus properties of the endocannabinoid catabolic enzyme inhibitor SA-57 in mice.
Owens et al.
J.Pharmacol.Exp.Ther, 2016;358:306
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