Catalog Number: 5772
Alternate Names: AHU 377
Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
Biological Activity
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.
Technical Data
  • M.Wt:
    430.52
  • Formula:
    C24H28NO5.½Ca
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1369773-39-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.
    Ksander et al.
    J.Med.Chem., 1995;38:1689

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