Sacubitril calcium

Tocris Bioscience | Catalog # 5772

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Tocris Bioscience

Key Product Details

Description

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

Alternative Names

AHU 377
View all Additional Synthetic Protease Inhibitors »

Product Description

Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Product Specifications for Sacubitril calcium

Molecular Weight

430.52

Formula

C24H28NO5.½Ca

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt

CAS Number

1369773-39-6

PubChem ID

91827885

InChI Key

DDLCKLBRBPYKQS-OXXXZDCLSA-L

SMILES

[Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.05 100
Ethanol 8.61 20

Preparing Stock Solutions for Sacubitril calcium

The following data is based on the product molecular weight 430.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.61 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Sacubitril calcium

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Sacubitril calcium

For research use only

Citations for Sacubitril calcium

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