SAG 21k

Tocris Bioscience | Catalog # 5282

Hedgehog signaling activator; brain penetrant and orally bioavailable
Tocris Bioscience

Key Product Details

Description

Hedgehog signaling activator; brain penetrant and orally bioavailable
View all Hedgehog Signaling Activators »

Product Description

SAG 21k is a potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant.

Product Specifications for SAG 21k

Molecular Weight

556.07

Formula

C29H28ClF2N3O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide

CAS Number

946002-48-8

PubChem ID

16678532

InChI Key

YVIFQUJDZSAFKG-UHFFFAOYSA-N

SMILES

COC1=C(CN([C@@H]2CC[C@@H](NC)CC2)C(C3=C(Cl)C4=C(C(F)=CC=C4F)S3)=O)C=C(C5=CC=NC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.61 100
Ethanol 11.12 20

Preparing Stock Solutions for SAG 21k

The following data is based on the product molecular weight 556.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.80 mL 8.99 mL 17.98 mL
5 mM 0.36 mL 1.80 mL 3.60 mL
10 mM 0.18 mL 0.90 mL 1.80 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for SAG 21k

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SAG 21k

For research use only

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