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SAG 21k

Catalog #: 5282 Datasheet / COA / SDS
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5282/10
SAG 21k | CAS No. 946002-48-8 | Hedgehog Signaling Activators
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Description: Hedgehog signaling activator; brain penetrant and orally bioavailable

Chemical Name: 3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide

Purity: ≥98%

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Biological Activity

SAG 21k is a potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
556.07
Formula:
C29H28ClF2N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
946002-48-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent agonists of the Hedgehog signaling pathway.
    Brunton et al.
    Bioorg.Med.Chem.Lett., 2009;19:4308

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