SAH-SOS1A

Tocris Bioscience | Catalog # 6920

KRas/SOS1 interaction inhibitor
Tocris Bioscience
Discontinued Product
6920 has been discontinued. View all Ras GTPase Inhibitors products.

Key Product Details

Description

KRas/SOS1 interaction inhibitor
View all Ras GTPase Inhibitors »

Product Description

SAH-SOS1A is a KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for SAH-SOS1A

Molecular Weight

2187.53

Formula

C100H159N27O28

Storage

Store at -20°C

CAS Number

1652561-87-9

SMILES

[H][C@](NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)([C@@H](C)CC)C(=O)N[C@@]1(C)CCCC=CCCC[C@](C)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for SAH-SOS1A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SAH-SOS1A

For research use only

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