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SAH-SOS1A

Catalog #: 6920 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6920/500U
SAH-SOS1A
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Description: KRas/SOS1 interaction inhibitor
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Biological Activity

SAH-SOS1A is a KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

Technical Data

M.Wt:
2187.53
Formula:
C100H159N27O28
Sequence:
RRFFGIXLTNXLKTEEGN

(Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-7 and X-11 stapled together with a double bond)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1652561-87-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
    Leshchiner et al.
    Proc.Natl.Acad.Sci.USA., 2015;112:1761

Product Datasheets

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