SAK 3

Catalog # Availability Size / Price Qty
6239/25
6239/5
Cat.No. 6239 - SAK 3 | C20H23N3O4 | CAS No. 1256269-87-0
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Description: Potent CaV3.1/3.3 activator; orally bioavailable

Chemical Name: Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

Purity: ≥98%

Product Details
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Biological Activity

Potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Technical Data

M.Wt:
369.41
Formula:
C20H23N3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1256269-87-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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