SAK 3

Key Product Details

Product Description

SAK 3 is a potent Ca_V3.1 and Ca_V3.3 activator. Enhances Ca_V3.1 and Ca_V3.3, but not Ca_V3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Product Specifications for SAK 3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SAK 3

The following data is based on the product molecular weight 369.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.54 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Xu T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 2018 PMID: 30196018
• Yabuki Pharmacological properties of SAK3, a novel T-type voltage-gated Ca²⁺ channel enhancer. Neuropharmacology 2017 PMID: 28093211

Product Documents for SAK 3