Catalog Number: 4712
Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
Biological Activity
Long-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).
Technical Data
  • M.Wt:
    603.75
  • Formula:
    C25H37NO4.C11H8O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    94749-08-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells.
    Akabane et al.
    Allergol.Int., 2006;55:387
  2. Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease.
    Rennard et al.
    Am.J.Respir.Crit.Care Med., 2001;163:1087
  3. The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma.
    Roberts et al.
    Eur.Respir.J., 1999;14:275
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Salmeterol xinafoate include:

4 Citations: Showing 1 - 4
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  1. ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas.
    Authors: Israël-Assayag Et al.
    Nat Commun 2015;10:e0120095
  2. Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists.
    Authors: Sykes and Charlton
    Br J Pharmacol 2012;165:2672
  3. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One 2011;6:e27474
  4. The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells.
    Authors: Scola Et al.
    Br J Pharmacol 2009;158:267

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