Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
Biological ActivityLong-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells.
Akabane et al.
Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease.
Rennard et al.
Am.J.Respir.Crit.Care Med., 2001;163:1087
The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma.
Roberts et al.
Citations for Salmeterol xinafoate
The citations listed below are publications that use Tocris products. Selected citations for Salmeterol xinafoate include:
7 Citations: Showing 1 - 7
The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.
Authors: Pon Et al.
FASEB J 2016;30:1144
ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas.
Authors: Israël-Assayag Et al.
Nat Commun 2015;10:e0120095
Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
Authors: Zaytseva Et al.
Sens Actuators B Chem 2013;188
Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists.
Authors: Sykes and Charlton
Br J Pharmacol 2012;165:2672
Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells.
Authors: Scola Et al.
Br J Pharmacol 2009;158:267
Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
Authors: Nackley Et al.
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