Catalog Number: 2347
Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Biological Activity
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress.
    Boyce et al.
    Science, 2005;307:935
  2. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
    Long et al.
    Bioorg.Med.Chem.Lett., 2005;15:3849
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