( 10 citations )    
Product Datasheet
Catalog Number:2347
Chemical Name:3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Product Details
Citations (10)
Biological Activity
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets

The citations listed below are publications that use Tocris products. Selected citations for Salubrinal include:

10 Citations: Showing 1 - 10
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  1. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
    Authors: Gandin Et al.
    Nat Commun  2016;7:11127
  2. Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy.
    Authors: Vandewynckel Et al.
    PLoS One  2015;9:93
  3. Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis.
    Authors: Hamamura Et al.
    J Musculoskelet Neuronal Interact  2015;4:84
  4. Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow.
    Authors: Wan Et al.
    PLoS One  2014;9:e105699
  5. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.
    Authors: Tran Et al.
    ACS Chem Biol  2014;9:2796
  6. Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
    Authors: Konrad Et al.
    Antimicrob Agents Chemother  2013;57:1815
  7. Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor β in cartilage and chondrocytes.
    Authors: Shim Et al.
    Hepatol Int  2013;13:372
  8. Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
    Authors: Hahn and Lowrey
    Blood  2013;122:477
  9. Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B.
    Authors: Bergeron Et al.
    J Biol Chem  2011;286:11242
  10. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells.
    Authors: Bennett Et al.
    Cell Death Dis  2011;1:e72


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