Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Biological ActivitySalvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..
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The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Salvinorin A: allosteric interactions at the μ-opioid receptor.
Rothman et al.
Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist.
Roth et al.
Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor.
Scheffler and Roth
Citations for Salvinorin A
The citations listed below are publications that use Tocris products. Selected citations for Salvinorin A include:
3 Citations: Showing 1 - 3
Salvinorin A reduces neuropathic nociception in the insular cortex of the rat.
Authors: Coffeen Et al.
Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo.
Authors: Mundra Et al.
J Pharmacol Exp Ther 2012;342:273
Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
Authors: Braida Et al.
Br J Pharmacol 2009;157:844
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