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Salvinorin A

2134 3 Citations Datasheet / COA / SDS
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Salvinorin A | CAS No. 83729-01-5 | Kappa Opioid Receptor Agonists
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Description: Highly potent and selective κ agonist
Alternative Names: Divinorin A

Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

Potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.

Technical Data

M.Wt:
432.47
Formula:
C23H28O8
Solubility:
Soluble to 10 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
83729-01-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Salvinorin A: allosteric interactions at the μ-opioid receptor.
    Rothman et al.
    J.Pharmacol.Exp.Ther., 2007;320:801
  2. Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist.
    Roth et al.
    Proc.Natl.Acad.Sci.USA, 2002;99:11934
  3. Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor.
    Scheffler and Roth
    TiPS., 2003;24:107

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Citations for Salvinorin A

The citations listed below are publications that use Tocris products. Selected citations for Salvinorin A include:

3 Citations: Showing 1 - 3

  1. Salvinorin A reduces neuropathic nociception in the insular cortex of the rat.
    Authors: Coffeen Et al.
    Eur.J.Pain.  2018;22:311
  2. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo.
    Authors: Mundra Et al.
    J Pharmacol Exp Ther  2012;342:273
  3. Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
    Authors: Braida Et al.
    Br J Pharmacol  2009;157:844

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VersaClone cDNA Plasmids

Rat KOR (NP_058863) VersaClone cDNA

RDC0433

Human KOR (NP_000903) VersaClone cDNA

RDC0145

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