Salvinorin A

Discontinued Product

2134 has been discontinued.
View all Kappa Opioid Receptor Agonists products.
Salvinorin A | CAS No. 83729-01-5 | Kappa Opioid Receptor Agonists
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Description: Highly potent and selective κ agonist
Alternative Names: Divinorin A

Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

Salvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.

Technical Data

Soluble to 10 mM in ethanol
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Salvinorin A: allosteric interactions at the μ-opioid receptor.
    Rothman et al.
    J.Pharmacol.Exp.Ther., 2007;320:801
  2. Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist.
    Roth et al.
    Proc.Natl.Acad.Sci.USA, 2002;99:11934
  3. Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor.
    Scheffler and Roth
    TiPS., 2003;24:107

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Citations for Salvinorin A

The citations listed below are publications that use Tocris products. Selected citations for Salvinorin A include:

3 Citations: Showing 1 - 3


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