Salvinorin A

Tocris Bioscience | Catalog # 2134

Highly potent and selective κ agonist
Tocris Bioscience
Discontinued Product
2134 has been discontinued. View all Kappa Opioid Receptor Agonists products.

Key Product Details

Description

Highly potent and selective κ agonist

Alternative Names

Divinorin A
View all Kappa Opioid Receptor Agonists »

Product Description

Salvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.

Product Specifications for Salvinorin A

Molecular Weight

432.47

Formula

C23H28O8

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

CAS Number

83729-01-5

PubChem ID

128563

InChI Key

OBSYBRPAKCASQB-AGQYDFLVSA-N

SMILES

O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](OC(C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 4.32 10

Preparing Stock Solutions for Salvinorin A

The following data is based on the product molecular weight 432.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.12 mL 115.61 mL 231.23 mL
0.5 mM 4.62 mL 23.12 mL 46.25 mL
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

  • Roth Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA
  • Scheffler and Roth Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS.
  • Rothman Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 2007 PMID: 17060492

Product Documents for Salvinorin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Salvinorin A

For research use only

Customer Reviews for Salvinorin A

There are currently no reviews for this product. Be the first to review Salvinorin A and earn rewards!

Have you used Salvinorin A?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card