Potent and selective κ
-opioid DREADD (KORD) activator (EC50
= 11.8 nM). Selective for KORD over endogenous κ
opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A
(Cat. No. 2134).
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior.
Vardy et al.
Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice.
Ansonoff et al.