Salvinorin B

Tocris Bioscience | Catalog # 5611

Activator of κ-opioid DREADD (KORD)
Tocris Bioscience

Key Product Details

Description

Activator of κ-opioid DREADD (KORD)
View all DREADD Activators »

Product Description

Salvinorin B is a potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A.

Product Specifications for Salvinorin B

Molecular Weight

390.43

Formula

C21H26O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

CAS Number

92545-30-7

PubChem ID

11440685

InChI Key

BLTMVAIOAAGYAR-CEFSSPBYSA-N

SMILES

O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.81 20

Preparing Stock Solutions for Salvinorin B

The following data is based on the product molecular weight 390.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.81 mL 64.03 mL 128.06 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
2 mM 1.28 mL 6.40 mL 12.81 mL
10 mM 0.26 mL 1.28 mL 2.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for Salvinorin B

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Salvinorin B

For research use only

Customer Reviews for Salvinorin B (1)

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  • Great version that works reliably
    Name: Melanie Pina
    Species: Human
    Assay Type: Ex Vivo
    Cell Line/Tissue: neuron
    Verified Customer | Posted 12/22/2019
    Great version that is easily dissolved in DMSO. Worked well in slice electrophysiology and produced reliable hyperpolarization in neurons expressing KOR DREADD at 100 nM.
    Salvinorin B 5611

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