SANT-1

Catalog # Availability Size / Price Qty
1974/10
1974/50
SANT-1 | CAS No. 304909-07-7 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Chemical Name: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

Purity: ≥99%

Product Details
Citations (8)
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Reviews

Biological Activity

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.

Technical Data

M.Wt:
373.5
Formula:
C23H27N5
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
304909-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small molecule modulation of smoothened activity.
    Chen et al.
    Proc.Natl.Acad.Sci., 2002;99:14071

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