Catalog Number: 1974
Chemical Name: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Biological Activity
Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule modulation of smoothened activity.
    Chen et al.
    Proc.Natl.Acad.Sci., 2002;99:14071

The citations listed below are publications that use Tocris products. Selected citations for SANT-1 include:

Showing Results 1 - 2 of 2

  1. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
    Authors: Nostro Et al.
  2. GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
    Authors: Atwood Et al.
    Stem Cell Reports
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