Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD
= 1.2 nM). Inhibits smoothened agonist effects with an IC50
of 20 nM (in Shh-LIGHT2 cells).
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All Tocris products are intended for laboratory research use only.
Small molecule modulation of smoothened activity.
Chen et al.
The citations listed below are publications that use Tocris products. Selected citations for SANT-1 include:
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