Chemical Name: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Biological ActivitySANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule modulation of smoothened activity.
Chen et al.
Citations for SANT-1
The citations listed below are publications that use Tocris products. Selected citations for SANT-1 include:
10 Citations: Showing 1 - 10
Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Authors: Yung Et al.
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
Authors: Sambathkumar Et al.
PLoS One 2018;13:e0197046
Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.
Authors: Krentz Et al.
Dev Cell 2017;41:129
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
Authors: Fleury Et al.
Sci Rep 2016;6:23479
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Authors: Yuan Et al.
Nat Commun 2016;21:11024
Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
Authors: Nostro Et al.
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
Authors: Hoch Et al.
FASEB J 2015;29:1817
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
Authors: Strating Et al.
Cell Rep 2015;10:600
GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
Authors: Atwood Et al.
Stem Cell Reports 2013;494:484
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Authors: Wang Et al.
Chem Biol 2012;19:972
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