SANT-1

  ( 4 citations )    
Product Datasheet
Catalog Number:1974
Chemical Name:N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Product Details
Citations (4)
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Reviews
Biological Activity
Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
Technical Data
  • M.Wt:
    373.5
  • Formula:
    C23H27N5
  • Solubility:
    Soluble to 25 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    304909-07-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SANT-1 include:

4 Citations: Showing 1 - 4
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  1. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
    Authors: Fleury Et al.
    Sci Rep  2016;6:23479
  2. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
    Authors: Nostro Et al.
    Neuropsychopharmacology  2015;4:591
  3. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
    Authors: Strating Et al.
    Cell Rep  2015;10:600
  4. GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
    Authors: Atwood Et al.
    Stem Cell Reports  2013;494:484

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