SANT-1

Catalog # Availability Size / Price Qty
1974/10
1974/50
SANT-1 | CAS No. 304909-07-7 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Chemical Name: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

Purity: ≥99%

Product Details
Citations (10)
Supplemental Products
Reviews

Biological Activity

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.

Technical Data

M.Wt:
373.5
Formula:
C23H27N5
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
304909-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small molecule modulation of smoothened activity.
    Chen et al.
    Proc.Natl.Acad.Sci., 2002;99:14071

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Citations for SANT-1

The citations listed below are publications that use Tocris products. Selected citations for SANT-1 include:

10 Citations: Showing 1 - 10

  1. Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
    Authors: Yung Et al.
    Nat.Commun.  2019;10:4647
  2. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
    Authors: Sambathkumar Et al.
    PLoS One  2018;13:e0197046
  3. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.
    Authors: Krentz Et al.
    Dev Cell  2017;41:129
  4. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
    Authors: Fleury Et al.
    Sci Rep  2016;6:23479
  5. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    Nat Commun  2016;21:11024
  6. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
    Authors: Nostro Et al.
    Neuropsychopharmacology  2015;4:591
  7. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
    Authors: Hoch Et al.
    FASEB J  2015;29:1817
  8. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
    Authors: Strating Et al.
    Cell Rep  2015;10:600
  9. GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
    Authors: Atwood Et al.
    Stem Cell Reports  2013;494:484
  10. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
    Authors: Wang Et al.
    Chem Biol  2012;19:972

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