Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein

Name: Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein
Brand: Novus Biologicals
SKU: NBP3-07080
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-07080

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices
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Key Product Details

Tag

His (N-Term)

Applications

SDS-PAGE

View all SARS-CoV-2 Membrane Protein Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a His (N-Term) tag corresponding to the amino acids Arg101-Gln222 of SARS-CoV-2 Membrane Protein

Source: E.coli

Accession: QHD43419.1

Purity

>90%, by SDS-PAGE quantitative densitometry by Coomassie Blue Staining

Predicted Molecular Mass

15.84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein

SDS-PAGE: Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein [NBP3-07080]

SDS-Page: Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein [NBP3-07080] - SDS-PAGE Image

Formulation, Preparation, and Storage

NBP3-07080

Formulation	PBS, pH 7.5, 0.02% NLS
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SARS-CoV-2 Membrane Protein

The SARS-CoV-2 Membrane protein is one of the four major structural proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 (1). The membrane protein is the most abundant of the four structural proteins, which also includes the envelope protein, spike protein, and nucleocapsid protein (1,2). The membrane protein is synthesized as a 222 amino acid protein with a theoretical molecular weight of 25.1 kDa (2,3). Furthermore, the membrane protein of SARS-CoV-2 has 90.5% sequence identity and 98.2% sequence similarity to that of the membrane protein of SARS-CoV (2). Structurally, the membrane protein is a type III transmembrane glycoprotein containing a glycosylated N-terminal ectodomain, three transmembrane domains, and a large C-terminal that extends into the viral particle (2,4). The membrane protein exists as a dimer and is either in long or compact conformation, which contributes to the curvature of the viral membrane (2,4). The main functions of the membrane protein are for viral assembly and contributing to the shape and structural integrity of the viral envelope (1,2). Additional functions show a role in inducing apoptosis as well as interactions with the spike and nucleocapsid proteins (1,2). The membrane-spike protein interaction is required for maintaining the spike protein within the ER-Golgi intermediate compartment (1). The membrane protein binding with the nucleocapsid protein is responsible for nucleocapsid stabilization and viral assembly (1).

References

1. Malik Y. A. (2020). Properties of Coronavirus and SARS-CoV-2. The Malaysian Journal of Pathology.

2. Yoshimoto F. K. (2020). The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19. The Protein Journal. https://doi.org/10.1007/s10930-020-09901-4

3. Uniprot (P0DTC5)

4. J Alsaadi, E. A., & Jones, I. M. (2019). Membrane binding proteins of coronaviruses. Future Virology. https://doi.org/10.2217/fvl-2018-0144

Alternate Names

2019-nCoV M protein, 2019-nCoV Membrane Protein, COVID-19 E1 Glycoprotein, COVID-19 Matrix glycoprotein, COVID-19 Membrane, COVID-19 Membrane glycoprotein, E1 glycoprotein, Human coronavirus Membrane Protein, Matrix glycoprotein, Membrane glycoprotein, Membrane Protein, SARS-CoV-2, SARS-CoV-2 E1 Glycoprotein, SARS-CoV-2 M Protein, SARS-CoV-2 Matrix glycoprotein, SARS-CoV-2 Membrane glycoprotein, SARSCoV2 Membrane Protein, Severe Acute Respiratory Syndrome Coronavirus 2

Gene Symbol

Additional SARS-CoV-2 Membrane Protein Products

Product Documents for Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant SARS-CoV-2 Membrane Protein His (N-Term) Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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