Spike S1 subunit refers to the N-terminal part of the coronavirus Spike protein. The S1 subunit contains an N-terminal domain in addition to the much-studied receptor binding domain (RBD). Spatially, the S1 subunit represents the most membrane-distal portion of the spike protein. For SARS-CoV-2, this subunit, specifically the RBD domain, is responsible for binding to ACE-2 on the surface of human cells and initiating viral entry. Because this interaction is so important for viral entry into host cells, the RBD domain has been the focus of therapeutic and vaccine development for COVID-19. The N-terminal domain of the S1 subunit may also be involved in receptor binding independent of ACE-2. Current research is underway to better understand this domain as it may unlock new therapeutic strategies to fight SARS-CoV-2.
SARS-CoV-2 Spike S1 Protein Antibody (1035224) [PE]
Novus Biologicals | Catalog # FAB105405P
Key Product Details
Species Reactivity
SARS-CoV-2
Applications
Blockade of Receptor-ligand Interaction
Label
PE (Excitation = 488 nm, Emission = 575 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # 1035224
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Product Specifications
Immunogen
HEK293-derived SARS-CoV-2 Spike S1 Subunit
Accession # YP_009724390.1
Accession # YP_009724390.1
Specificity
Detects SARS-CoV-2 Spike S1 RBD and SARS-CoV-2 B.1.1.529 S RBD (Omicron Variant) in direct ELISAs
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [PE]
Application
Recommended Usage
Blockade of Receptor-ligand Interaction
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
PBS
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Spike S1 Subunit
Long Name
Spike Protein, S1 Subunit
Alternate Names
SARS-CoV-2
Additional Spike S1 Subunit Products
Product Documents for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [PE]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for SARS-CoV-2 Spike S1 Protein Antibody (1035224) [PE]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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