SATA (Succinimidyl 2-(acetylthio)acetate) is a reagent for the covalent modification of primary amines. Adds sulfhydryl groups to amine-containing biomolecules, such as proteins and antibodies, enabling conjugation with other molecules. SATA can be conjugated to antibodies and coupled with lipid nanoparticles (LNPs) modified with DSPE-PEG-maleimide (Cat. No. 7947).

Product Specifications for SATA

Molecular Weight

231.20

Formula

C₈H₉NO₅S

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

Succinimidyl 2-(acetylthio)acetate

CAS Number

76931-93-6

PubChem ID

127532

InChI Key

FLCQLSRLQIPNLM-UHFFFAOYSA-N

SMILES

O=C(ON1C(=O)CCC1=O)CSC(=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Breda In vivo hematopoietic stem cell modification by mRNA delivery. Science 2023 PMID: 37499029
Rurik CAR T cells produced in vivo to treat cardiac injury. Science 2022 PMID: 34990237
Tombácz Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs. Mol.Therapy 2021 PMID: 34091054
Parhiz PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake. J.Control.Release 2018 PMID: 30336167

Product Documents for SATA

Certificate of Analysis

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Download SDS

Product Specific Notices for SATA

For research use only

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SATA

Tocris Bioscience | Catalog # 8145

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