Chemical Name: (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[220.127.116.11,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
Biological ActivityHigh affinity DPP-IV inhibitor (Ki = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zuckerfa/fa rats.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Saxagliptin hydrochloride
Average Rating: 5 (Based on 1 Review)
Have you used Saxagliptin hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Guinea pig hearts were isolated and mounted on a Langendorff's setup followed by perfusion with Krebs-Henseleit solution alone or containing saxagliptin (2 µM) for 30 min. The protocol of Langendorff perfusion of isolated guinea pig hearts is displayed in the upper panel. Saxagliptin significantly impaired left ventricular developed pressure compared to controls.