Saxagliptin hydrochloride

Catalog # Availability Size / Price Qty
6507/10
6507/50
Cat.No. 6507 - Saxagliptin hydrochloride | C18H25N3O2.HCl | CAS No. 709031-78-7
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Description: High affinity DPP-IV inhibitor; active in vivo
Alternative Names: BMS 477118

Chemical Name: (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

High affinity DPP-IV inhibitor (Ki = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zuckerfa/fa rats.

Technical Data

M.Wt:
351.87
Formula:
C18H25N3O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
709031-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Saxagliptin impairs cardiac contractility
By Christopher Trummer on 10/15/2018
Species: Other

Guinea pig hearts were isolated and mounted on a Langendorff's setup followed by perfusion with Krebs-Henseleit solution alone or containing saxagliptin (2 µM) for 30 min. The protocol of Langendorff perfusion of isolated guinea pig hearts is displayed in the upper panel. Saxagliptin significantly impaired left ventricular developed pressure compared to controls.


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