Saxagliptin hydrochloride

Tocris Bioscience | Catalog # 6507

High affinity DPP-IV inhibitor; active in vivo
Tocris Bioscience

Key Product Details

Description

High affinity DPP-IV inhibitor; active in vivo

Alternative Names

BMS 477118
View all DPPIV/CD26 Inhibitors »

Product Description

Saxagliptin hydrochloride is a high affinity DPP-IV inhibitor (Ki = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zuckerfa/fa rats.

Product Specifications for Saxagliptin hydrochloride

Molecular Weight

351.87

Formula

C18H25N3O2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride

CAS Number

709031-78-7

PubChem ID

56841574

InChI Key

TUAZNHHHYVBVBR-RIKNOMPASA-N

SMILES

N[C@@H](C12CC3CC(C2)CC(C3)(C1)O)C(N4[C@H]5C[C@H]5C[C@H]4C#N)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.19 100
DMSO 35.19 100

Preparing Stock Solutions for Saxagliptin hydrochloride

The following data is based on the product molecular weight 351.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Saxagliptin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Saxagliptin hydrochloride

For research use only

Related Research Areas

Serine Proteases and Regulators

Citations for Saxagliptin hydrochloride

Customer Reviews for Saxagliptin hydrochloride (1)

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  • Saxagliptin impairs cardiac contractility
    Name: Christopher Trummer
    Species: Guinea Pig
    Assay Type: Ex Vivo
    Cell Line/Tissue: heart
    Verified Customer | Posted 10/15/2018
    Guinea pig hearts were isolated and mounted on a Langendorff's setup followed by perfusion with Krebs-Henseleit solution alone or containing saxagliptin (2 µM) for 30 min. The protocol of Langendorff perfusion of isolated guinea pig hearts is displayed in the upper panel. Saxagliptin significantly impaired left ventricular developed pressure compared to controls.
    Saxagliptin hydrochloride 6507

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