Potent and selective 5-HT4
receptor antagonist (pIC50
= 10.1). Displays >5000-fold selectivity for 5-HT4
, and 5-HT3
receptors. Exhibits anxiolytic activity upon systemic administration in vivo
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Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
Bingham et al.
(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 antagonist derived from metoclopramide.
Gaster et al.
An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestine circular muscle.
Prins et al.