Catalog Number: 0921
Alternate Names: TAN 67
Chemical Name: (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
Biological Activity
The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).
Technical Data
  • M.Wt:
    506.28
  • Formula:
    C23H24N2O.2HBr
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    1217628-73-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice.
    Kamei et al.
    Eur.J.Pharmacol., 1995;276:131
  2. Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors.
    Knap et al.
    Eur.J.Pharmacol., 1995;291:129
  3. The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation.
    Nagase et al.
    Life Sci., 2001;68:2227
  4. Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships.
    Nagase et al.
    Jpn.J.Pharmacol., 1994;64:Suppl. 1, 35P

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