receptor antagonist (pKi
values are 7.0, 8.1 and 9.1 at 5-HT2A
receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C
receptor function. Orally active in vivo
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Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist.
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Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic ag
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