SB 228357

Key Product Details

Product Description

SB 228357 is a 5-HT_2C/2B receptor antagonist (pK_i values are 7.0, 8.1 and 9.1 at 5-HT_2A, _2B and _2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT_2C receptor function. Orally active in vivo.

Licensing Information

Sold under license

Product Specifications for SB 228357

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 228357

The following data is based on the product molecular weight 431.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.18 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Reavill Attenuation of haloperidol-induced catalepsy by a 5-HT_2C receptor antagonist. Br.J.Pharmacol. 1999 PMID: 10188965
• Bromidge Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic ag J.Med.Chem. 2000 PMID: 10737744

Product Documents for SB 228357