SB 242084

Tocris Bioscience | Catalog # 2901

Selective 5-HT2C antagonist; brain penetrant
Tocris Bioscience
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Key Product Details

Description

Selective 5-HT2C antagonist; brain penetrant
View all 5-HT2C Receptor Antagonists »

Product Description

SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.

Licensing Information

Sold with the permission of GlaxoSmithKline

Usage Guidelines

This product is sold as an xHCl salt. The stoichiometry of the salt and hydration levels vary from batch to batch. It is sold in gross weight with the batch specific Molecular Weight available on the Certificate of Analysis.

Product Specifications for SB 242084

Formula

C21H19ClN4O2.xHCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrochloride

PubChem ID

16219981

InChI Key

WOKOGXKQXNESDA-UHFFFAOYSA-N

SMILES

O=C(NC1=CN=C(OC2=CC=CN=C2C)C=C1)N3C4=C(CC3)C=C(C)C(Cl)=C4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 23.39mg/ml in DMSO

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 100 publications citing the usage of this product.

Product Documents for SB 242084

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 242084

For research use only

Customer Reviews for SB 242084 (1)

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  • This product is good for in vitro experiment.
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: CHO
    Verified Customer | Posted 06/03/2020
    After reaching 80% confluence, cells were treated with the selective 5-HT2CR antagonist SB242084 (300nM) or the 5-HT1BR antagonist SB216641 (1 µM), applied 10 minutes prior to agonist application.
    300nM
    SB 242084 2901

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