receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A
receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.
Soluble to 50 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of GlaxoSmithKline
6-Chloro-5-methyl-1-[[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.
Bromidge et al.
SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.
Kennet et al.
Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse.
Dalton et al.
The citations listed below are publications that use Tocris products. Selected citations for SB 242084 include:
Showing Results 1 - 7 of 7