SB 277011A dihydrochloride

Key Product Details

Product Description

SB 277011A dihydrochloride is a selective dopamine D₃ receptor antagonist (pK_i values are 8.0, 6.0, 5.0 and <5.2 for D₃, D₂, 5-HT_1D and 5-HT_1B respectively). Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for SB 277011A dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 277011A dihydrochloride

The following data is based on the product molecular weight 511.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.91 mL	19.55 mL	39.10 mL
2.5 mM	0.78 mL	3.91 mL	7.82 mL
5 mM	0.39 mL	1.96 mL	3.91 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Stemp Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective DA D3 receptor antagonist with high oral bioavailability and CNS pe J.Med.Chem. 2000 PMID: 10794704
• Reavill Pharmacological actions of a novel, high-affinity, and selective human DA D₃ receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 2000 PMID: 10945872

Product Documents for SB 277011A dihydrochloride