SB 290157 trifluoroacetate

Catalog # Availability Size / Price Qty
SB 290157 trifluoroacetate | CAS No. 1140525-25-2 | Complement Signaling inhibitors
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Description: Potent C3a receptor antagonist

Chemical Name: N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate

Purity: ≥97%

Product Details

Biological Activity

Potent C3a receptor antagonist (IC50 values are 27 - 30 nM for C3a-induced Ca2+ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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