SB 290157 trifluoroacetate
Chemical Name: N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate
Biological ActivityPotent C3a receptor antagonist (IC50 values are 27 - 30 nM for C3a-induced Ca2+ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.
Ames et al.
C3aR and C5aR1 act as key regulators of human and mouse β-cell function.
Atanes et al.
Cell Mol.Life Sci., 2018;75:715
Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways.
Hu et al.
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