SB 290157 trifluoroacetate New
Chemical Name: N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate
Biological ActivityPotent C3a receptor antagonist (IC50 values are 27 - 30 nM for C3a-induced Ca2+ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.
Ames et al.
C3aR and C5aR1 act as key regulators of human and mouse β-cell function.
Atanes et al.
Cell Mol.Life Sci., 2018;75:715
Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways.
Hu et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for SB 290157 trifluoroacetate
There are currently no reviews for this product. Be the first to review SB 290157 trifluoroacetate and earn rewards!
Have you used SB 290157 trifluoroacetate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image