Selective non-peptide orexin OX1
receptor antagonist (Kb
values are 21.7 and 1405 nM for human OX1
receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo
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Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.
Langmead et al.
Advances in novel 7-TM receptors: non-peptide orexin-1 antagonists.
Royal Society of Chemistry Meeting., 2001;
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