Chemical Name: N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Biological ActivitySelective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.
Langmead et al.
Advances in novel 7-TM receptors: non-peptide orexin-1 antagonists.
Royal Society of Chemistry Meeting., 2001;
Citations for SB 408124
The citations listed below are publications that use Tocris products. Selected citations for SB 408124 include:
2 Citations: Showing 1 - 2
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Authors: Suo Et al.
Front Endocrinol (Lausanne) 2018;9:647
Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.
Authors: Urbałska Et al.
BMC Cancer 2012;46:42561
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