SB 408124

Catalog # Availability Size / Price Qty
1963/10
SB 408124 | CAS No. 288150-92-5 | OX1 Receptor Antagonists
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Description: Selective non-peptide OX1 antagonist

Chemical Name: N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

Technical Data

M.Wt:
356.37
Formula:
C19H18F2N4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
288150-92-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.
    Langmead et al.
    Br.J.Pharmacol., 2004;141:340
  2. Advances in novel 7-TM receptors: non-peptide orexin-1 antagonists.
    Porter
    Royal Society of Chemistry Meeting., 2001;

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Citations for SB 408124

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2 Citations: Showing 1 - 2

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