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SB 4

Catalog #: 6881
1 Citation Datasheet / COA / SDS
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6881/50

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SB 4 | CAS No. 100874-08-6 | BMP and Other Activin Receptor Activators
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Description: Potent BMP4 agonist

Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SB 4 is a potent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors. When used in combination, SB 4 enhances BMP4 signaling and embryonic stem cell differentiation.

Technical Data

M.Wt:
320.2
Formula:
C14H10BrNOS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
100874-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for SB 4

The citations listed below are publications that use Tocris products. Selected citations for SB 4 include:

1 Citation: Showing 1 - 1

  1. A comparison between BMP4 and SB4 in inducing germ line gene expression pattern during embryonic stem cells differentiation.
    Authors: Hayaei Tehrani Et al.
    Differentiation  2022;123:9

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