Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole
Biological ActivityPotent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.
Bradford et al.
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