SB 4

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SB 4 | CAS No. 100874-08-6 | BMP and Other Activin Receptor Activators
1 Image
Description: Potent BMP4 agonist

Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

SB 4 is a potent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors. When used in combination, SB 4 enhances BMP4 signaling and embryonic stem cell differentiation.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for SB 4

The citations listed below are publications that use Tocris products. Selected citations for SB 4 include:

1 Citation: Showing 1 - 1


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