Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole
Biological ActivitySB 4 is a potent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors. When used in combination, SB 4 enhances BMP4 signaling and embryonic stem cell differentiation.
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High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.
Bradford et al.
Citation for SB 4
The citations listed below are publications that use Tocris products. Selected citations for SB 4 include:
1 Citation: Showing 1 - 1
A comparison between BMP4 and SB4 in inducing germ line gene expression pattern during embryonic stem cells differentiation.
Authors: Hayaei Tehrani Et al.
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