SB 4
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Description: Potent BMP4 agonist
Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole
Purity: ≥99%
Biological Activity
Potent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors.Technical Data
M.Wt:
320.2
Formula:
C14H10BrNOS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
100874-08-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.
Bradford et al.
J.Biol.Chem., 2019;294:3125
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