Catalog Number: 3263
Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Biological Activity
Selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.
Technical Data
  • M.Wt:
    335.4
  • Formula:
    C20H21N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    694433-59-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7.
    Byfield et al.
    Mol.Pharmacol., 2004;65:744
  2. Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells.
    Hu et al.
    Am.J.Physiol.Renal Physiol., 2005;289:F816
  3. The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
    Noma et al.
    Gastroenterology, 2008;134:1981
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 505124 include:

Showing Results 1 - 2 of 2

  1. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
    Authors: Boxtel Et al.
    Dev Cell
  2. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.
    Authors: Ramel and Hill
    Dev Biol
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