Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Biological ActivitySB 505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells.
Hu et al.
Am.J.Physiol.Renal Physiol., 2005;289:F816
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
Noma et al.
SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7.
Byfield et al.
Citations for SB 505124
The citations listed below are publications that use Tocris products. Selected citations for SB 505124 include:
5 Citations: Showing 1 - 5
Establishment of mouse expanded potential stem cells.
Authors: Yang Et al.
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis.
Authors: Asghar Et al.
Oncol Lett 2017;14:5497
Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.
Authors: Zhu Et al.
A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
Authors: Boxtel Et al.
Dev Cell 2015;35:175
The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.
Authors: Ramel and Hill
Dev Biol 2013;378:170
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