SB 505124

  ( 3 citations )    
Product Datasheet
Catalog Number:3263
Chemical Name:2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.
Technical Data
  • M.Wt:
    335.4
  • Formula:
    C20H21N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    694433-59-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 505124 include:

3 Citations: Showing 1 - 3
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  1. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.
    Authors: Zhu Et al.
    Oncogene  2016;35:5388
  2. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
    Authors: Boxtel Et al.
    Dev Cell  2015;35:175
  3. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.
    Authors: Ramel and Hill
    Dev Biol  2013;378:170

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human TGF-beta RI/ALK-5 (NP_004603) VersaClone cDNA

RDC1294
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Human Activin RIB/ALK-4 (NP_004293) VersaClone cDNA

RDC1202
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Mouse TGF-beta RI/ALK-5 (NP_033396) VersaClone cDNA

RDC0709
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