Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Biological ActivitySelective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells.
Hu et al.
Am.J.Physiol.Renal Physiol., 2005;289:F816
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
Noma et al.
SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7.
Byfield et al.
Citations for SB 505124
The citations listed below are publications that use Tocris products. Selected citations for SB 505124 include:
5 Citations: Showing 1 - 5
Establishment of mouse expanded potential stem cells.
Authors: Yang Et al.
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis.
Authors: Asghar Et al.
Oncol Lett 2017;14:5497
Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.
Authors: Zhu Et al.
A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
Authors: Boxtel Et al.
Dev Cell 2015;35:175
The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.
Authors: Ramel and Hill
Dev Biol 2013;378:170
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