Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Biological ActivitySB 525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis.
Grygielko et al.
Inhibition of AVNreceptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis
Higashiyama et al.
Tumor-specific efficacy of transforming growth factor-βRI inhibition in eker rats.
Laping et al.
Clin.Cancer Res., 2007;13:3087
Citations for SB 525334
The citations listed below are publications that use Tocris products. Selected citations for SB 525334 include:
7 Citations: Showing 1 - 7
Increased transforming growth factor beta (TGF-β) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury.
Authors: Kilari Et al.
Sci Rep 2018;8:6630
RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
Authors: Gutiérrez Et al.
Lab Chip 2015;10:e0135005
An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
Authors: Kleczko Et al.
PLoS One 2015;10:e0123600
MicroRNA-214 antagonism protects against renal fibrosis.
Authors: Denby Et al.
J Am Soc Nephrol 2014;25:65
Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
Authors: Grygielewicz Et al.
Gastric Cancer 2014;
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
Sci Rep 2013;13:1969
Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors.
Authors: Ng Et al.
Clin Cancer Res 2012;18:4122
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