SB 525334

  ( 6 citations )    
Product Datasheet
Catalog Number:3211
Chemical Name:6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.
Technical Data
  • M.Wt:
    343.42
  • Formula:
    C21H21N5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    356559-20-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 525334 include:

6 Citations: Showing 1 - 6
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  1. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice.
    Authors: Gutiérrez Et al.
    Lab Chip  2015;10:e0135005
  2. An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
    Authors: Kleczko Et al.
    PLoS One  2015;10:e0123600
  3. MicroRNA-214 antagonism protects against renal fibrosis.
    Authors: Denby Et al.
    J Am Soc Nephrol  2014;25:65
  4. Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
    Authors: Grygielewicz Et al.
    Gastric Cancer  2014;
  5. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
    Authors: Li Et al.
    Sci Rep  2013;13:1969
  6. Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors.
    Authors: Ng Et al.
    Clin Cancer Res  2012;18:4122

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