SB 525334

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3211/10
3211/50
SB 525334 | CAS No. 356559-20-1 | TGF-beta Receptor Inhibitors
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Description: Selective inhibitor of TGF-βRI

Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Purity: ≥97%

Product Details
Citations (7)
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Biological Activity

Selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

Technical Data

M.Wt:
343.42
Formula:
C21H21N5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
356559-20-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

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Citations for SB 525334

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