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SB 699551

3188 Datasheet / COA / SDS
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3188/10
3188/50
SB 699551 | CAS No. 864741-95-7 | 5-HT5 Receptor Antagonists
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Description: Selective 5-ht5a antagonist

Chemical Name: N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride

Purity: ≥99%

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Biological Activity

SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).

Technical Data

M.Wt:
584.66
Formula:
C34H45N3O.2HCl
Solubility:
Soluble to 25 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
864741-95-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. 5-ht5A receptors as a therapeutic target.
    Thomas
    Pharmacol.Ther., 2006;111:707
  2. Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.
    Corbett et al.
    Bioorg.Med.Chem.letts., 2005;15:4014
  3. SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto
    Thomas et al.
    Neuropharmacology, 2006;51:566

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VersaClone cDNA Plasmids

Human 5-HT5A (NP_076917) VersaClone cDNA

RDC0249

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