Catalog Number: 3188
Chemical Name: N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride
Biological Activity
Selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).
Technical Data
  • M.Wt:
    584.66
  • Formula:
    C34H45N3O.2HCl
  • Solubility:
    Soluble to 25 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    864741-95-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto
    Thomas et al.
    Neuropharmacology, 2006;51:566
  2. 5-ht5A receptors as a therapeutic target.
    Thomas
    Pharmacol.Ther., 2006;111:707
  3. Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.
    Corbett et al.
    Bioorg.Med.Chem.letts., 2005;15:4014

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