SB 699551

Key Product Details

Product Description

SB 699551 is a selective 5-ht_5a receptor antagonist (pK_i values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht_5a, 5-HT_1B/D, 5-HT_2A, 5-HT_2C, 5-HT_1A and 5-HT₇ receptors respectively).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 699551

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 699551

The following data is based on the product molecular weight 584.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.84 mL	34.21 mL	68.42 mL
1.25 mM	1.37 mL	6.84 mL	13.68 mL
2.5 mM	0.68 mL	3.42 mL	6.84 mL
12.5 mM	0.14 mL	0.68 mL	1.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Thomas 5-ht_5A receptors as a therapeutic target. Pharmacol.Ther. 2006 PMID: 16516972
• Corbett Discovery of a potent and selective 5-ht_5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 2005 PMID: 16002289
• Thomas SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto Neuropharmacology 2006 PMID: 16846620

Product Documents for SB 699551