Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Biological ActivityActivator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Jo et al.
Citations for SC 79
The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:
5 Citations: Showing 1 - 5
Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
Authors: Wang Et al.
Stem Cell Res Ther 2017;8:245
miR-382 targeting PTEN-Akt axis promotes liver regeneration.
Authors: Bei Et al.
Mol Syst Biol 2016;7:1584
SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
Authors: Wilson Et al.
Sci Rep 2016;6:17735
A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
Authors: Moreira Et al.
J Transl Med 2015;13:76
The bimodally expressed microRNA miR-142 gates exit from pluripotency.
Authors: Sladitschek and Neveu
Sci Rep 2015;11:850
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for SC 79
Average Rating: 5 (Based on 1 Review)
Have you used SC 79?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Cells were treated with 5 um SC79 to activate AKT