Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Biological ActivitySC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
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Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Jo et al.
Citations for SC 79
The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:
5 Citations: Showing 1 - 5
Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
Authors: Wang Et al.
Stem Cell Res Ther 2017;8:245
miR-382 targeting PTEN-Akt axis promotes liver regeneration.
Authors: Bei Et al.
Mol Syst Biol 2016;7:1584
SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
Authors: Wilson Et al.
Sci Rep 2016;6:17735
A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
Authors: Moreira Et al.
J Transl Med 2015;13:76
The bimodally expressed microRNA miR-142 gates exit from pluripotency.
Authors: Sladitschek and Neveu
Sci Rep 2015;11:850
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Cells were treated with 5 um SC79 to activate AKT