Catalog Number: 4635
Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Biological Activity
Activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
    Jo et al.
    Proc.Natl.Acad.Sci.USA, 2012;109:10581

The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:

Showing Results 1 - 4 of 4

  1. miR-382 targeting PTEN-Akt axis promotes liver regeneration.
    Authors: Bei Et al.
    Mol Syst Biol
  2. SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
    Authors: Wilson Et al.
    Sci Rep
  3. A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
    Authors: Moreira Et al.
    J Transl Med
  4. The bimodally expressed microRNA miR-142 gates�exit from pluripotency.
    Authors: Sladitschek and Neveu
    Sci Rep
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