Activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro
and in vivo
. Exhibits brain penetrance.
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Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Jo et al.
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