Home / Akt (Protein Kinase B) Activators / SC 79

SC 79

Catalog #: 4635
5 Citations 1 Review Datasheet / COA / SDS
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4635/50
SC 79 | CAS No. 305834-79-1 | Akt (Protein Kinase B) Activators
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Description: Akt activator

Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Product Details
Citations (5)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Technical Data

M.Wt:
364.78
Formula:
C17H17ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
305834-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

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Citations for SC 79

The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:

5 Citations: Showing 1 - 5

  1. Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
    Authors: Wang Et al.
    Stem Cell Res Ther  2017;8:245
  2. miR-382 targeting PTEN-Akt axis promotes liver regeneration.
    Authors: Bei Et al.
    Mol Syst Biol  2016;7:1584
  3. SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
    Authors: Wilson Et al.
    Sci Rep  2016;6:17735
  4. A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
    Authors: Moreira Et al.
    J Transl Med  2015;13:76
  5. The bimodally expressed microRNA miR-142 gates exit from pluripotency.
    Authors: Sladitschek and Neveu
    Sci Rep  2015;11:850

FAQs

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VersaClone cDNA Plasmids

Human Akt1 (NP_005154) VersaClone cDNA

RDC1993

Human Akt2 (NP_001617) VersaClone cDNA

RDC1994

Human Akt3 (NP_005456) VersaClone cDNA

RDC2161

Reviews for SC 79

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in vitro teatment
By Anonymous on 04/05/2019
Species: Mouse

Cells were treated with 5 um SC79 to activate AKT

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