SCH 28080
Chemical Name: 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Purity: ≥99%
Biological Activity
SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Gastric antisecretory and cytoprotective activities of SCH 28080.
Long et al.
J.Pharmacol.Exp.Ther., 1983;226:114 -
Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080.
Scott et al.
Biochem.Pharmacol., 1987;36:97 -
SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain.
Vagin et al.
Biochemistry, 2002;41:12755
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Citation for SCH 28080
The citations listed below are publications that use Tocris products. Selected citations for SCH 28080 include:
1 Citation: Showing 1 - 1
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Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.
Authors: Lynch Et al.
Am J Physiol Renal Physiol 2010;298:F408
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