SCH 28080

Key Product Details

Product Description

SCH 28080 is a potent inhibitor of H⁺,K⁺-ATPase (IC₅₀ = 20 nM); binds to the K⁺ recognition site and is competitive with respect to K⁺. Inhibits gastric acid secretion in vitro and in vivo.

Product Specifications for SCH 28080

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SCH 28080

The following data is based on the product molecular weight 277.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.42 mL	72.12 mL	144.23 mL
1.25 mM	2.88 mL	14.42 mL	28.85 mL
2.5 mM	1.44 mL	7.21 mL	14.42 mL
12.5 mM	0.29 mL	1.44 mL	2.88 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Scott Studies on the mechanism of action of the gastric microsomal (H⁺K⁺)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 1987 PMID: 3026407
• Vagin SCH 28080, a K⁺-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K⁺ access to the ion binding domain. Biochemistry 2002 PMID: 12379118
• Long Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 1983 PMID: 6864535

Product Documents for SCH 28080