Catalog Number: 1414
Chemical Name: (α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide
Biological Activity
Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
Technical Data
  • M.Wt:
    384.27
  • Formula:
    C17H21NO4.HBr
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    114-49-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats.
    Jones and Shannon
    Eur.J.Pharmacol., 2000;391:105
  2. An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters.
    Parkes
    Psychopharmacologia, 1965;7:1
  3. Cerebral blood flow responses to somatosensory stimulation are unaffected by scopolamine in unanesthetized rat.
    Nakao et al.
    J.Pharmacol.Exp.Ther., 1999;290:929
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Scopolamine hydrobromide include:

9 Citations: Showing 1 - 9
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  1. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports 2016;6:37834
  2. Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
    Authors: Parent Et al.
    Proc Natl Acad Sci U S A 2015;9:284
  3. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Front Behav Neurosci 2015;4
  4. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurosci 2015;112:8124
  5. Phasic dopamine release drives rapid activation of striatal D2-receptors.
    Authors: Marcott Et al.
    Neuron 2014;84:164
  6. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.
    Authors: Chuhma Et al.
    Elife 2014;81:901
  7. Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium.
    Authors: Field Et al.
    J Neurosci 2012;32:6288
  8. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One 2011;6:e19155
  9. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience 2009;164:1068

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