Catalog Number: 3035
Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
Biological Activity
JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.
    Duan et al.
    Mol.Pharmacol., 2007;72:1137
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