SD 208

  ( 6 citations )    
Product Datasheet
Catalog Number:3269
Chemical Name:2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
Product Details
Citations (6)
Supplemental Products
Biological Activity
Potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for SD 208 include:

6 Citations: Showing 1 - 6
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  1. TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.
    Authors: Pavlides Et al.
    Cell Cycle  2016;15:931
  2. Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.
    Authors: Seliger Et al.
    Cell Cycle  2016;15:1755
  3. Protons sensitize epithelial cells to mesenchymal transition.
    Authors: Wang Et al.
    PLoS One  2012;7:e41249
  4. Transforming growth factor-β evokes Ca2+ waves and enhances gene expression in human pulmonary fibroblasts.
    Authors: Mukherjee Et al.
    Am J Respir Cell Mol Biol  2012;46:757
  5. Transforming growth factor-β regulates the growth of valve interstitial cells in vitro.
    Authors: Li and Gotlieb
    Am J Pathol  2011;179:1746
  6. Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome.
    Authors: Nistala Et al.
    PLoS One  2010;19:4790


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