SD 208

  ( 6 citations )    
Product Datasheet
Catalog Number:3269
Chemical Name:2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.
Technical Data
  • M.Wt:
    352.75
  • Formula:
    C17H10ClFN6
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    627536-09-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SD 208 include:

6 Citations: Showing 1 - 6
Filter your results:

  1. TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.
    Authors: Pavlides Et al.
    Cell Cycle  2016;15:931
  2. Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.
    Authors: Seliger Et al.
    Cell Cycle  2016;15:1755
  3. Protons sensitize epithelial cells to mesenchymal transition.
    Authors: Wang Et al.
    PLoS One  2012;7:e41249
  4. Transforming growth factor-β evokes Ca2+ waves and enhances gene expression in human pulmonary fibroblasts.
    Authors: Mukherjee Et al.
    Am J Respir Cell Mol Biol  2012;46:757
  5. Transforming growth factor-β regulates the growth of valve interstitial cells in vitro.
    Authors: Li and Gotlieb
    Am J Pathol  2011;179:1746
  6. Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome.
    Authors: Nistala Et al.
    PLoS One  2010;19:4790

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used SD 208?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee