SDZ 205-557 hydrochloride

Catalog # Availability Size / Price Qty
SDZ 205-557 hydrochloride | CAS No. 1197334-02-3 | 5-HT4 Receptor Antagonists
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Description: 5-HT3 and 5-HT4 antagonist

Chemical Name: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride

Purity: ≥99%

Product Details
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Biological Activity

SDZ 205-557 hydrochloride is a 5-HT3/5-HT4 receptor antagonist.

Technical Data

Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors.
    Eglen et al.
    Br.J.Pharmacol., 1993;108:376
  2. Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.
    McMahon and Cunningham
    J.Pharmacol.Exp.Ther., 1999;291:300
  3. SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum.
    Buchheit et al.
    Naunyn-Schmied.Arch.Pharmacol., 1992;345:387

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