SDZ SER 082 fumarate

Key Product Details

Product Description

SDZ SER 082 fumarate is a selective 5-HT_2B/2C receptor antagonist with low affinity for 5-HT_1A receptors. Inhibits [³H]-mesulergine binding to 5-HT_2C receptors with a pK_D of 7.8. Inhibits 5-HT_2B mediated responses in the rat fundus (pK_B = 7.34).

Licensing Information

Sold with the permission of Novartis Pharma AG

Product Specifications for SDZ SER 082 fumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SDZ SER 082 fumarate

The following data is based on the product molecular weight 344.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.52 mL	29.04 mL
5 mM	0.58 mL	2.90 mL	5.81 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mora Role of 5-HT_2A and 5-HT_2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 1997 PMID: 9408213
• Nozulak (+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT_2C/2B receptor antagonist with low 5-HT_2A receptor affinity. J.Med.Chem. 1995 PMID: 7837236
• Kalkman Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 1998 PMID: 9570468

Product Documents for SDZ SER 082 fumarate