Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Biological ActivitySec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance.
Hafner et al.
The cytohesin Steppke is essential for insulin signalling in Drosophila.
Fuss et al.
Citation for SecinH3
The citations listed below are publications that use Tocris products. Selected citations for SecinH3 include:
1 Citation: Showing 1 - 1
Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.
Authors: Risse Et al.
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