Catalog Number: 2849
Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Biological Activity
Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
Technical Data
  • M.Wt:
    460.5
  • Formula:
    C24H20N4O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    853625-60-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance.
    Hafner et al.
    Nature, 2006;444:941
  2. The cytohesin Steppke is essential for insulin signalling in Drosophila.
    Fuss et al.
    Nature, 2006;444:945
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SecinH3 include:

1 Citations: Showing 1 - 1

  1. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.
    Authors: Risse Et al.
    Pain 2011;300:L958

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