Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Biological ActivitySec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of cytohesins by secinH3 leads to hepatic Ins resistance.
Hafner et al.
The cytohesin Steppke is essential for Ins signalling in Drosophila.
Fuss et al.
Citations for SecinH3
The citations listed below are publications that use Tocris products. Selected citations for SecinH3 include:
4 Citations: Showing 1 - 4
Authors: Abdul-Salam Et al.
Circ Res 2019;124:52
Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
Authors: Ford Et al.
PLoS Pathog 2018;14:e1007051
Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.
Authors: Guichard Et al.
PLoS Pathog 2017;13:e1006603
Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.
Authors: Risse Et al.
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