Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50
values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μ
M for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance.
Hafner et al.
The cytohesin Steppke is essential for insulin signalling in Drosophila.
Fuss et al.
The citations listed below are publications that use Tocris products. Selected citations for SecinH3 include:
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