Human Serpin E1/PAI-1 ELISA Kit (Colorimetric)

Key Product Details

Product Specifications

Precision

Intra-Assay Precision (Precision within an assay) CV% 3.70% (example only; lot dependent)

Inter-Assay Precision (Precision between assays) CV% 9.50% (example only; lot dependent)

Recovery for Human Serpin E1/PAI-1 ELISA Kit (Colorimetric)

Scientific Data Images for Human Serpin E1/PAI-1 ELISA Kit (Colorimetric)

Preparation and Storage

Background: Serpin E1/PAI-1

PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.

Additional Serpin E1/PAI-1 Products

• All Products for Serpin E1/PAI-1
• Serpin E1/PAI-1 cDNA Clones
• Serpin E1/PAI-1 ELISA Kits
• Serpin E1/PAI-1 Luminex Assays
• Serpin E1/PAI-1 Lysates
• Serpin E1/PAI-1 Primary Antibodies
• Serpin E1/PAI-1 Proteins and Enzymes
• Serpin E1/PAI-1 Simple Plex

Product Documents for Human Serpin E1/PAI-1 ELISA Kit (Colorimetric)